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initial dose

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  • Dose-volume histogram — (DVH), a concept used in radiation treatment planning[1]. DVHs were introduced by Goitein and Verhey in 1979 in a publication by Shipley et al.[2]. The purpose of a DVH is to summarize 3D dose distributions in a graphical 2D format. In modern… …   Wikipedia

  • dose — 1. The quantity of a drug or other remedy to be taken or applied all at one time or in fractional amounts within a given period. Cf.:dosage (2). 2. In nuclear medicine, amount of energy absorbed per unit mass of irradiated material (absorbed d.) …   Medical dictionary

  • Dose-response relationship — Semi log plots of two agonists with different Kd. The dose response relationship, or exposure response relationship, describes the change in effect on an organism caused by differing levels of exposure (or doses) to a stressor (usually a… …   Wikipedia

  • Initial volume of distribution — The initial volume of distribution is a pharmacological term used to quantify the distribution of a drug throughout the body relatively soon after oral or intravenous dosing of a drug and prior to the drug reaching a steady state equilibrium.… …   Wikipedia

  • First dose phenomenon — The first dose phenomenon is a sudden and severe fall in blood pressure that can occur when changing from a lying to a standing position the first time that an alpha blocker drug is used [ Prazosin: the first dose phenomenon. Graham RM, Thornell… …   Wikipedia

  • loading dose — n a large initial dose of a substance or series of such doses given to rapidly achieve a therapeutic concentration in the body * * * a dose of medication, often larger than subsequent doses, administered to establish a therapeutic level of the… …   Medical dictionary

  • booster dose — a dose of an active immunizing agent, usually smaller than the initial dose, given to maintain immunity …   Medical dictionary

  • Loading dose — A loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose.[1] A loading dose is most useful for drugs that are eliminated from the body… …   Wikipedia

  • Median lethal dose — This article is about the toxicological term. For the album by Mudvayne, see L.D. 50 (album). For other uses, see LD50 (disambiguation). In toxicology, the median lethal dose, LD50 (abbreviation for “Lethal Dose, 50%”), LC50 (Lethal Concentration …   Wikipedia

  • Metered-dose inhaler — ProAir HFA Albuterol Sulfate(US) A metered dose inhaler (MDI) is a device that delivers a specific amount of medication to the airway and lungs, in the form of a short burst of aerosolized medicine that is inhaled by the patient. It is the most… …   Wikipedia

  • International Centre for Low Dose Radiation Research — The International Centre for Low Dose Radiation Research (ICLDRR) was established at the University of Ottawa, in 1997, with national and international support. The ICLDRR assembles all published data and conducts analyses concerning the effects… …   Wikipedia

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